I like to work it backwards. Define what job needs to be done first, then choose the tool that does that job best.
When it comes to rifles, this often equates to intended engagement range. Whether you are in tactical shooting, hunting, home defense, or competition, the goal is to get your sights on target and make a clean shot that will hit as quickly as possible. For a rifle that will only be used out to 100 yards, this usually means a red dot, unless you have astigmatism or other eye issues that don't get along well with red dots (shameless industry shilling here for our new 1x CYCLOPS prism scope red dot alternative). For a rifle that will be used out to 300 yards, a fixed power prism scope can often get the job done for less money. For a rifle that will be used out to 600 yards, get an LPVO. And beyond 600 yards, you are going to have to give up a lot of speed up close in exchange for being able to see and hit at medium to long range.
I'm a huge fan of LPVOs if you are trying to build a "do it all" rifle with the most flexibility possible. But they aren't the best for any one situation. A red dot is faster than 1-6x set to 1x at room-clearing distances, and there are other factors to consider as well like the brightness of the reticle illumination, battery life, weight and bulk, and cost. I can get you set up with a kick ass micro dot that weighs 5 ounces, has battery life measured in years, and has a lifetime warranty for about $200 with a riser mount for your AR. But our latest 1-6x "Raptor" LPVO is $400 without any mount at all, is almost a foot long and weighs more than a pound. And it's STILL an amazing value compared to the competition.
So, there's a lot to think about.