If you are using TSX or the Blue tip versions, then you can run around 19/WW 296, this gives you around 2355 fps at 16 inches at 10.5 inches anything from 2160 to 2250 depending on the gun/barrel..........This runs around 53000 PSI........
The best Barnes version for 300 BLK is the Barnes 110 TAC, it is designed for 300 BLK and proves it both loading and terminals. I use 19.5/WW 296 for 2405-2425 in 16 inches of gun and 2250 in 10.5 inches, 2200 in 8.5 inches......... 56000 PSI, just a tad over my limits of 55000 PSI for these type guns.....
I run nothing but WW 296........
Both Barnes bullets are very good, accurate, and terminally serious..... The only thing that beats them is the 100 FB Raptors.......... for accuracy/terminals.................