I recall a .30-’06 Sprg.-chambered rifle that was just terrible with everything except the near-obsolete 220-gr. round-nose. Go figure. I had a Remington Mountain rifle in .280 Rem. that shot patterns—not groups—with all factory loads then available, but with handloaded 140-gr. Nosler AccuBonds it was instantly a tack driver. Be exhaustive in your search for the right loads. As with most things in accuracy, improvements are usually incremental and rarely exponential.
https://www.americanrifleman.org/articles/2017/8/2/troubleshooting-rifle-accuracy/
https://www.americanrifleman.org/articles/2017/8/2/troubleshooting-rifle-accuracy/