I have a bunch of studies that say otherwise. Now if you want to discuss the assertion to some meds (specifically cholesterol meds), I am all ears: that stuff has changed so much in the past 25 years it's crazy. But the anti-hypertensives, diuretics, and anti-dysrhythmics, the science is pretty sound. But, research is always going on, so things change.
First, I hate meds. I hate taking meds. I hate when people go on meds. I think for most meds, if people can get off them at some point, they should.
Second, it IS true that the 81 mg is more GI protective; plus, the half-life is shorter. People confuse it with being a blood thinner, and it's not. It's mechanism is totally different. Plus, there's about 50 other things for which ASA is beneficial; it's a great medication for those who can take it. The dosing is weird because it's a conversion from grains, a holdover from ye olden days. 325 is such an arbitrary number, but even the low dosing there's virtually no difference between 75 mg and 81 mg.
As for eating well and moving, this would cure so many ills it's not funny....